Polygonum hydropiper L. is a traditionally usedmedicinal plant. The present studywas designed\nto explore the Alpha-amylase inhibitory, antioxidant, and antimicrobial activities of Polygonum hydropiper L.\nPolarity-based solvent extracts (n-hexane, acetone, chloroform, methanol, ethanol, and water) of\nPolygonum hydropiper leaves and stem were used. Antioxidant activity was assessed by free radical\nscavenging assay (FRAP) and 2,2-diphenylpicrylhydrazyl (DPPH) free radical scavenging activity\nmethods. Quantitative phytochemical analyses suggested that the stem of Polygonum hydropiper L.\ncontains higher levels of bioactive compounds than its leaves (p < 0.05). The results suggested that\nstem-derived extracts of Polygonum hydropiper L. are more active against bacterial species, including\ntwo Gram-positive and three Gram-negative strains. Moreover, our results showed that the bioactive\ncompounds of Polygonum hydropiper L. significantly inhibit Alpha-amylase activity. Finally, we reported\nthe polarity-based solvent extracts of Polygonum hydropiper L. and revealed that the stem, rather than\nleaves, has a high antioxidant potential as measured by FRAP and DPPH assay with IC50 values of\n1.38 and 1.59 mg/mL, respectively. It may also be deducted from the data that the Polygonum hydropiper\nL. could be a significant candidate, which should be subjected to further isolation and characterization,\nto be used as an antidiabetic, antimicrobial and antioxidant resource in many industries, like food,\npharmaceuticals and cosmetics.
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